styrene cancer reddit

Just this week, the National Research Council (NRC) signed off on the National Toxicology Program’s decision to list styrene … Views expressed here do not necessarily reflect those of ScienceDaily, its staff, its contributors, or its partners. ScienceDaily shares links with sites in the. Styrene is the precursor … Oxford University Press is a department of the University of Oxford. Content on this website is for information only. (6) styrene review paper ‘that no consistent increased risk of any cancer among workers exposed to styrene was found. He is professor in occupational medicine, at the Department of Clinical Medicine at Aarhus University as well as Aarhus University Hospital. Styrene Officially Linked to Cancer Styrene Officially Linked to Cancer. Or view hourly updated newsfeeds in your RSS reader: Keep up to date with the latest news from ScienceDaily via social networks: Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. But in a time when new studies on cancer links make news weekly, it’s easy to lose sight of the clear and consistent evidence: many common cancers have their roots in lifestyle factors. "Possibly carcinogenic and should be investigated more closely." 12th Report on Carcinogens, National Toxicology Program, Cytogenetic and DNA damage on workers exposed to styrene, Styrene metabolism, genotoxicity, and potential carcinogenicity, Styrene Oxide CAS No. In March, the 23 researchers in the WHO working group spent ten intensive working days in Lyon, where they had the task of reviewing and re-evaluating the carcinogenic risk based on the latest research on styrene exposure which includes epidemiological studies of humans together with animal experiments and what are known as mechanism studies. and their health effects. What is styrene? http://ntp.niehs.nih.gov/files/20081216SIRC.pdf (accessed June 20, 2011), Occupational exposure to solvents and risk of lymphoma subtypes: results from the Epilymph case-control study, Cancer incidence among petrochemical workers in the Porto Torres industrial area, 1990–2006, Cancer incidence among petrochemical workers in the Porto Torres industrial area, Styrene, styrene oxide, polystyrene, and beta-nitrostyrene/styrene carcinogenicity in rodents, Carcinogenicity and mechanistic insights on the behavior of epoxides and epoxide-forming chemicals, Chemicals studied and evaluated in long-term carcinogenesis bioassays by both the Ramazzini Foundation and the National Toxicology Program: in tribute to Cesare Maltoni and David Rall, Predicting chemicals causing cancer in animals as human carcinogens, Alleged misconceptions' distort perceptions of environmental cancer risks, Role of experimental and epidemiological evidence of carcinogenicity in the primary prevention of cancer, Identification of carcinogenic agents and primary prevention of cancer, Prevention versus chemophobia: a defence of rodent carcinogenicity tests, Long-term chemical carcinogenesis bioassays predict human cancer hazards. Financial support for ScienceDaily comes from advertisements and referral programs, where indicated. This fact sheet answers the most frequently asked health questions (FAQs) about styrene. In 2011, styrene, a high volume plastics chemical and animal carcinogen, was the focal point in a ‘poison scandal’ in the Danish media; but now a registry study of more than 72,000 employees from more than 400 companies that have been exposed to styrene during production of glassfibre reinforced plastics, has not found an increased incidence of a wide range of cancer … "That part of the study is primarily based on measurements that the Danish Working Environment Authority carried out a number of years ago, since the Danish Working Environment Authority has not carried out measurements of styrene over the past several years. The World Health Organization’s International Agency for Research on Cancer (IARC) has now upgraded the cancer-causing status of the common plastic ingredient styrene. Issues, controversies, and uncertainties. One example is the monograph, which recently showed that diesel exhaust can cause lung cancer. Moreover, in 2009 (1), the US Department of Health and Human Service’s NTP declared ‘Styrene is reasonably anticipated to be a human carcinogen based on limited evidence of carcinogenicity in humans, sufficient evidence of carcinogenicity in experimental animals, and supporting mechanistic data.’, NTP further affirms, regarding human studies (1), that: ‘The limited evidence for the carcinogenicity of styrene in humans is based on studies of workers exposed to styrene that showed (1) increased mortality from or incidence of cancer of the lymphohematopoietic system and (2) increased levels of DNA adducts and genetic damage in lymphocytes from exposed workers. Styrene is widely used in the manufacture of synthetic rubber, resins, polyesters and plastics. Chapter 1, The Case for Styrene… hide. The mere fact that there’s a super-ominous warning about cancer and birth defects without any information regarding why it’s here, what materials of the product may cause cancer and in what way and if there are special handling pre-cautions that can be taken to avoid the danger makes me lose trust in the producer and assume the … Other countries have done nothing. Interestingly, nearly 25 years ago and confirmed 10 years ago IARC concluded that there was already evidence for the carcinogenicity of styrene in animals (5). Styrene is a colorless liquid that evaporates easily. (6) concluded that the available epidemiologic evidence does not support a causal relationship between styrene exposure and any type of human cancer’ (2). Questions? Styrene is upgraded from possibly carcinogenic to probably carcinogenic for humans, and the decision is largely based on register-based studies from Aarhus together with new animal evidence. Out of the more than 70,000 people included in the research project, we found 25 cases of acute myeloid leukaemia, where you would statistically expect to find 10," says Professor Henrik Kolstad with reference to the research article 'Styrene exposure and risk of lymphohematopoietic malignancies in 73,036 reinforced plastics workers', published in Epidemiology. Le formaldéhyde, substance présente notamment dans les matières plastiques, et le styrène font désormais partie de la liste des produits cancérigènes. Another example is the monograph that last year found that the herbicide glyphosate, better known as Roundup, can be carcinogenic. Don't take our word for it, click on the linked chapters to have a look at some actual pages from the book in PDF format. The move came in response to the results of a comprehensive study carried out by researchers from Aarhus University, along with new animal … Methods. However, a causal relationship between styrene exposure and cancer in humans is credible and is supported by the finding of DNA adducts and chromosomal aberrations in lymphocytes from styrene-exposed workers.’ The NTP conclusion that styrene is ‘reasonably anticipated to be a human carcinogen’ based on induced cancers… Back-up Slides Styrene Exposure Scenarios . Although some studies suggest that styrene-exposed workers may be at increased cancer risk, the human evidence for styrene carcinogenicity is inconclusive. The Department of Occupational Medicine at Aarhus University in Denmark has concluded that styrene may cause cancer in humans. What about other health effects? Is that only an issue if the tv gets smashed or something? Significant improvements have been made to the working environments in the Danish reinforced plastics industry in recent years, but globally the problem has not been solved. Exposure to styrene may increase the risk of cancer. Elevated incidence or mortality of lymphohematopoietic cancers was observed in large occupational cohorts of workers in the reinforced … wind turbines or yachts. A practical nomogram and risk stratification system predicting the cancer-specific survival for patients with early hepatocellular carcinoma. The authors (2) quote correctly that the ‘International Agency for Research on Cancer (IARC) classified styrene as possibly carcinogenic to humans (Group 2B) and SO as probably carcinogenic to humans (Group 2A)’. (8) who reported significantly elevated risks for B-cell non-Hodgkin’s lymphoma [odds ratio (OR) = 1.6; 95% confidence interval (CI) = 1.1–2.3] and for follicular lymphoma (OR = 2.6; 95% CI = 1.3–5.2) in relation to styrene exposure. There is sparse and inconsistent evidence of an association between styrene exposure and cancer. Aarhus University. Reddit; Founded in 1976 ... the singer has revealed she’s battling breast cancer. "After 40 years in limbo: Styrene is probably carcinogenic." However, it was not possible to establish whether the American workers contracted leukaemia from handling styrene or from butadiene, a chemical, which is styrene's permanent companion in the production of synthetic rubber -- and this is where the Danish register-based studies come into the picture. Styrene found in plastic products is linked with leukemia and nasal cancer risk, revealed research Aarhus University, Denmark. Enough already The styrene toxicity database available today provides ample support for a conclusion of “no concern” for styrene and cancer. In its pure form, styrene has a sweet smell. The scientific effort to describe the potential for styrene exposure to cause cancer in humans may be entering its last phase. For possible other human cancer sites related to styrene exposures, NTP asserts ‘Studies in the reinforced-plastics industry provided evidence that suggests a possible association between styrene exposure and cancer of the esophagus or pancreas.’ (1). About the United Kingdom Environmental Mutagen Society, http://ntp.niehs.nih.gov/?objectid=BD1A20B5-F1F6-975E-7CF8CBFACF0FC7EF, http://ntp.niehs.nih.gov/ntp/roc/twelfth/profiles/StyreneOxide.pdf, http://www.ehjournal.net/content/10/S1/S14, Receive exclusive offers and updates from Oxford Academic, Comparison of genotoxic potency of styrene 7,8-oxide with γ radiation and human cancer risk estimation of styrene using the rad-equivalence approach, Styrene monomer does not induce unscheduled DNA synthesis in the mouse liver following inhalation exposure. Conflict of interest statement: None declared. However, a causal relationship between styrene exposure and cancer in humans is credible and is supported by the finding of DNA adducts and chromosomal aberrations in lymphocytes from styrene-exposed workers.’. Moreover, in the interests of public and occupational health, we suggest that authors be more cautious in their casual acceptance of industry papers and reviews of epidemiological study results related to occupational exposure to styrene (or other chemicals). Experience shows that countries respond differently to the warnings of the monographs. 100-42-5. Styrene and the primary metabolite styrene-7,8-oxide are genotoxic and carcinogenic. 100% Upvoted. Long-term chemical carcinogenesis bioassays showed that styrene caused lung cancers in several strains of mice and mammary cancers in rats and styrene-7,8-oxide caused tumours of the forestomach in rats and mice and of the liver in mice. 0.75 0.01 0.76 Forced … Note: Content may be edited for style and length. Styrene (vinyl benzene) is an economically important industrial chemical used in the synthesis and manufacture of polystyrene and hundreds of different copolymers, as well as numerous other industrial resins. Monographs are impartial research reports, which assess the strength of evidence for carcinogenic effects so that individual countries have a qualified basis for legislation. UPR Sector Group of Cefic 17 . Cancer Studies in Humans The limited evidence for the carcinogenicity of styrene in humans is based on studies of workers exposed to styrene that showed (1) in-creased mortality from or incidence of cancer of the lymphohemato- poietic system and (2) increased levels of DNA adducts and genetic damage in lymphocytes from exposed workers. Styrene - ToxFAQs™ CAS # 100-42-5. ScienceDaily. For forty years, this has been the conclusion of researchers who have been unsure of whether there is an increased risk of cancer associated with styrene. Mette Skovgaard Christensen, Jesper Medom Vestergaard, Francesco d’Amore, Jette Sønderskov Gørløv, Gunnar Toft, Cecilia Høst Ramlau-Hansen, Zara Ann Stokholm, Inge Brosbøl Iversen, Mette Schou Nissen, Henrik Albert Kolstad. We have therefore mapped the cancer incidence for those who worked in companies that used styrene in the production during the period 1968-2011," explains Henrik Kolstad on the background for what has ended up being the world's largest epidemiological study of styrene exposure in the reinforced plastics industry. Four styrene laden products to ditch. Published by Oxford University Press on behalf of the UK Environmental Mutagen Society. Styrene is on the Proposition 65 list because it can cause cancer. "We've tried to make it clear that a listing in the report doesn't necessarily mean that encountering that substance in any minute quantity means you'll get cancer," said NTP Associate Director John Bucher. WARNING: This product contains a chemical known to the State of California to cause cancer, birth defects or other reproductive harm. However, the types of lymphohematopoietic cancer observed in excess varied across different cohort studies, and excess risks were not found in all cohorts. Reasonably Anticipated to Be a Human Carcinogen. The Factors That Do Increase Cancer Risk. To further explore the relationship between work-related styrene exposure and cancer, NIOSH investigators compared styrene exposures to cancer deaths among 5,201 former workers in two boat-building facilities in Washington State. Additionally, increases in cancer ‘at these sites were also observed in some of the individual cohort studies, and there was some evidence of an exposure–response relationship with pancreatic cancer’ (1). Reddit; Wechat; Abstract. Share on Reddit; WeChat; Email; Print; To send an e-mail to multiple recipients, separate e-mail addresses with a comma, semicolon, or both. The latter cover cause-effect studies based on biological material. Share on Reddit; WeChat; Email; Print; To send an e-mail to multiple recipients, separate e-mail addresses with a comma, semicolon, or both. "After 40 years in limbo: Styrene is probably carcinogenic." The new announcement from the World Health Organisation will be published by IARC as a Monograph, authored by 23 handpicked researchers from around the world, including Professor Henrik Kolstad. 12th Report on Carcinogens, National Toxicology Program, Some traditional herbal medicines, some mycotoxins, naphthalene and styrene, Epidemiologic studies of styrene and cancer: a review of the literature, RE: Request for NTP to Fully Consider New Styrene Epidemiology Review Prior to Finalizing Styrene Draft Substance Profile, 16 Dec 2008, 3 page letter to Wilson SH, NIEHS from Synder J, SIRC. Background. Well there’s a new development around the health effects of styrene, that’s been hotly contested for years. Styrene is a colorless to yellow liquid that is highly flammable and evaporates easily. ScienceDaily. Government scientists effectively have seen just enough evidence to posit a link between styrene and cancer, but not enough for ironclad proof. Le styrène ne figurant pas sur la liste européenne des produits cancérogènes, il n’y a pas d’obligation d’appliquer le décret 2001-97 du 1er février 2001, dit décret CMR. For permissions, please e-mail: journals.permissions@oup.com. In some studies, the risks increased with increasing measures of exposure, such as average exposure, cumulative exposure, or number of years since first exposure. Search for other works by this author on: Styrene. (9) in 2010 likewise demonstrated significantly elevated risks in petrochemical workers exposed to styrene when data for all categories of non-Hodgkin’s lymphoma are combined (Standardized Incidence Ratio = 1.87, 95% CI = 1.01–2.99, based on 15 cases) (10). There are no strong or consistent indications that styrene causes any form of cancer in humans. Proposition 65 requires businesses to determine if they must provide a warning about exposure to listed chemicals. The Boffetta et al. Styrene Modeling includes detailed, how-to modeling advice from more than a dozen accomplished craftsmen who have built every conceivable type of styrene model. This fact sheet is one in a series of summaries about hazardous substances . "But in the instance of styrene… The NTP independent Board was not swayed or particularly impressed with the analysis and conclusions of the Boffetta et al. . (2), however, dismissed IARC’s Working Group evaluation in 2002 (5) by iterating from the 2009 Boffetta et al. It's a handbook no modeler should be without. The NTP conclusion that styrene is ‘reasonably anticipated to be a human carcinogen’ based on induced cancers, genotoxicity and mechanism is further bolstered by the 2010 case–control study in six European countries by Cocco et al. Sciences study of Styrene and cancer. There is also some evidence for increased risks of esophageal and pancreatic cancer among styrene-exposed workers. Causality is not established, as the possibility that the results were due to chance or to confounding by exposure to other carcinogenic chemicals cannot be completely ruled out. 2 comments . Hearing … The reason for different classifications from different organizations is partly a … Four styrene laden products to ditch Planning a summer barbecue this weekend or stocking up for Labor Day? No adequate human studies are available for styrene-7,8-oxide although this is the primary and active epoxide metabolite of styrene. The facilities have since closed but, when operational, manufactured boats using styrene … The critical impact of tumor size in predicting cancer special survival for T3aM0M0 renal cell carcinoma: A proposal of an alternative T3aN0M0 stage. The issue of styrene and cancer has been a priority for IARC ever since an accumulation of leukaemia cases among employees in the American synthetic rubber industry was seen in the 1970s. Exposure-related trend analyses also demonstrated increased risks (P < 0.05) for lymphomas in relation to increases in styrene exposures. 96-09-3. Styrene has been classified by the International Agency for Research on Cancer (IARC) as Group 2A, probably carcinogenic to humans, based on limited human and sufficient animal evidence. Styrene news and market information products from ICIS. Another important research result is a fivefold risk for a particular type of nasal cancer following styrene exposure. Just this week, the National Research Council (NRC) signed off on the National Toxicology Program’s decision to list styrene … Government Agency reviews also concluded that styrene and its major metabolite styrene-7,8-oxide (SO) are both mutagenic and clastogenic as well as carcinogenic (1,4). ScienceDaily, 30 May 2018. The conclusion that diets can play a role in lowering or increasing cancer … share. save. Standardized … Both are genotoxic and form DNA adducts in humans. Four styrene-laden products to ditch. Styrene is an industrial chemical used to produce a number of different … review (6,7). James Huff, Peter F. Infante, Styrene exposure and risk of cancer, Mutagenesis, Volume 26, Issue 5, September 2011, Pages 583–584, https://doi.org/10.1093/mutage/ger033. The most robust studies are a 2-year inhalation study in CD-1 mice and a 2-year oral gavage study in B6C3F1 mice, showing significantly increased incidences of lung tumours in male and female CD-1 mice, in male B6C3F1 mice and in both sexes of O20 mice (1,11–13). Some scientists think it’s already over. "Possibly carcinogenic and should be investigated more closely." Elevated risks of lymphohematopoietic cancer were found among workers with higher exposure to styrene after an appropriate elapsed time since first exposure. Based on biological material and nasal cancer following styrene exposure to styrene After an appropriate elapsed since... Cancer-Specific survival for T3aM0M0 renal cell carcinoma: a proposal of an association styrene... Higher exposure to listed chemicals for a conclusion of “ no concern ” for and! Provide medical or other professional advice national Institute of Environmental health Sciences, national of... 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